Reproducible R workflow that generates bulk RNA-seq from single-cell references, injects batch/biology effects, and compares correction methods (ComBat, limma, RUV, fastMNN, SVA) using quantitative metrics and plots. Outputs are bulk-level assays (bulk_counts).
benchmarking rna-seq r simulation pca bioconductor combat single-cell limma ruv sva batch-correction bulk-rna-seq sc-rna-seq summarizedexperiment fastmnn
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Updated
Sep 11, 2025 - R