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mrazomej/README.md

About Me

I’m a Scientist II in Computational Biology at Altos Labs, developing probabilistic machine learning methods and biophysical models to understand biological systems.

My research spans single-cell genomics, evolutionary dynamics, and gene regulation. I combine statistical physics, generative modeling, and Bayesian inference to ask: what can we reliably learn from noisy biological measurements?

How I Approach Research

I move between mechanistic models, statistical inference, and deep learning according to the biological question. My experience performing experiments—including fluorescence microscopy—shapes how I model measurements, test predictions, and interpret uncertainty.

Statistical physics and dynamical systems provide a foundation for connecting molecular mechanisms to cellular behavior. Probabilistic machine learning helps me bring that understanding to complex, high-dimensional data.

I build scientific software that makes these methods usable: explicit assumptions, reusable components, reproducible analyses, and documentation that connects the code to the science.

Scientific Software

  • BarBay.jl — Bayesian inference of relative fitness from high-throughput DNA barcode competition assays, with uncertainty quantification and models for multiple environments and experimental replicates. Documentation
  • AutoEncoderToolkit.jl — Tools for training variational autoencoders and their extensions, including geometric analysis of learned latent spaces. Documentation
  • SCRIBE — Probabilistic modeling of single-cell RNA-seq data with explicit treatment of measurement noise and uncertainty, using GPU-accelerated inference in JAX and NumPyro. Source code is currently private; publication in preparation.

Background

Previously, I was a Schmidt Science Fellow and postdoctoral researcher at Stanford, working with Dmitri Petrov and collaborating with Madhav Mani at Northwestern University. My work focused on Bayesian fitness inference and geometry-aware representation learning for evolutionary landscapes.

I earned my PhD in Biochemistry and Molecular Biophysics at Caltech with Rob Phillips, combining statistical physics, information theory, and experiments to study how genetic circuits process environmental signals.

Research & publications · Personal website

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  1. BarBay.jl BarBay.jl Public

    Repository for the BarBay Julia package for Bayesian inference of relative fitness on barcode sequencing data.

    Julia 4

  2. AutoEncoderToolkit.jl AutoEncoderToolkit.jl Public

    Julia package with several functions to train and analyze Autoencoder-based neural networks

    Julia 25

  3. phd phd Public

    The repository containing everything related to my PhD thesis

    TeX