OPEN-SOURCE · GLOBAL & TARGET ANALYSIS · TIME-RESOLVED · SPECTROSCOPY · FLIM · MULTI-WAY DATA
Open-source tools for global and target analysis of time-resolved spectroscopy, fluorescence lifetime imaging, and multi-way data — from photosynthesis and photovoltaics to photochemistry and beyond.
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| 2007 TIMP | ──→── | 2012 Glotaran | ──→── | 2023 pyglotaran |
Decompose your data. Discover your kinetics.
pyglotaran · Flagship · Python
A Python framework for global and target analysis of time-resolved spectroscopy, microscopy, and other multi-way data. Models are described in composable YAML files, fit with partitioned variable projection, and results visualised directly in Jupyter notebooks.
- Modular model definitions — combine kinetic megacomplexes from reusable building blocks
- Simultaneous multi-dataset fitting — link parameters across related experiments
- Partitioned variable projection — efficient, numerically stable nonlinear least squares
- Python-native — results stay in xarray and integrate naturally with matplotlib and Jupyter
| Package | Language | Status | Summary |
|---|---|---|---|
| pyglotaran-extras | Python | active | Visualization companion — publication-ready overview plots and diagnostic figures |
| TIMP | R | stable | Foundational R engine for partitioned variable projection, on CRAN since 2007 |
| paramGUI | R | stable | Shiny app for teaching parameter estimation examples inspired by time-resolved spectroscopy |
| Glotaran 1.x | Java | archived | Original GUI for TIMP — still the most-cited tool in the field (1,500+ citations) |
| Year | Paper |
|---|---|
| 2023 | pyglotaran: a lego-like Python framework for global and target analysis of time-resolved spectra van Stokkum IHM, Weißenborn J, Weigand S, Snellenburg JJ · Photochemical & Photobiological Sciences |
| 2012 | Glotaran: A Java-Based Graphical User Interface for the R Package TIMP Snellenburg JJ, Laptenok SP, Seger R, Mullen KM, van Stokkum IHM · Journal of Statistical Software |
| 2007 | TIMP: An R package for modeling multi-way spectroscopic measurements Mullen KM, van Stokkum IHM · Journal of Statistical Software |
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