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YaaOppong/README.md

Yaa Oppong

I work on ML and AI for biology, health and pharmaceuticals.

PhD in computational biology (LSHTM), applying machine learning and genome-wide association methods to bacterial genomics. Industry experience at AstraZeneca and BenevolentAI. Currently applying LLMs and foundation models to problems in biotech and pharma, with a particular focus on validation and provenance.

rbcl-generative-biology Prompt-conditioned generation and LoRA fine-tuning of a genomic foundation model (Evo 2) on rbcL. Corpus built with species-level leakage control and stratified splits; reproducible evaluation harness with memorisation controls. Manuscript in preparation.

kegg-string-mcp An MCP server exposing KEGG, STRING and PubMed as model-callable tools, with an agentic annotation pipeline that validates every citation against what was actually retrieved.

ccrcc-target-triage Drug-blind, multi-omic triage of candidate drug targets in clear cell renal carcinoma, using public proteogenomic data. Runs its own recovery test against known positives and reports the result either way.

womens-health-ml Whether passive wearable data can predict menstrual cycle phase. Reports a negative finding rather than a flattering one.


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  1. ccrcc-target-triage ccrcc-target-triage Public

    Drug-blind, expression-driven triage of surface/secreted targets in clear cell RCC using CPTAC proteogenomics. Protein/RNA concordance and a data-driven immune-decoy filter narrow 11,710 proteins t…

    Python

  2. womens-health-ml womens-health-ml Public

    Does passive wearable data predict menstrual cycle phase? On the mcPHASES dataset, cycle timing alone (macro-F1 0.64) beats physiology, symptoms, and every combination, under leave-one-subject-out …

    Python

  3. kegg-string-mcp kegg-string-mcp Public

    LLM workflow to annotate genes with provenance and verification: MCP server exposing KEGG, STRING and PubMed as model-callable tools, plus an agentic annotation pipeline that verifies every citatio…

    Python 1

  4. rbcl-generative-biology rbcl-generative-biology Public

    Prompt-conditioned generation and LoRA finetuning of Evo 2 on rbcL, with a reproducible evaluation harness

    Python